Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease

Innate immunity is associated with Alzheimer disease (AD)(1), however, the influence of immune activation on Aβ production is unknown(2,3). Here, we identify interferon-induced transmembrane protein 3 (IFITM3) as a γ-secretase modulatory protein, establishing a mechanism by which inflammation impact...

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Detalles Bibliográficos
Autores principales: Hur, Ji-Yeun, Frost, Georgia R., Wu, Xianzhong, Crump, Christina, Pan, Si Jia, Wong, Eitan, Barros, Marilia, Li, Thomas, Nie, Pengju, Zhai, Yujia, Wang, Jen Chyong, TCW, Julia, Guo, Lei, McKenzie, Andrew, Ming, Chen, Zhou, Xianxiao, Wang, Minghui, Sagi, Yotam, Renton, Alan E., Esposito, Bianca T., Kim, Yong, Sadleir, Katherine R., Trinh, Ivy, Rissman, Robert A., Vassar, Robert, Zhang, Bin, Johnson, Douglas S., Masliah, Eliezer, Greengard, Paul, Goate, Alison, Li, Yue-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919141/
https://www.ncbi.nlm.nih.gov/pubmed/32879487
http://dx.doi.org/10.1038/s41586-020-2681-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919141/
https://www.ncbi.nlm.nih.gov/pubmed/32879487
http://dx.doi.org/10.1038/s41586-020-2681-2

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