XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence

Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant to cancer, we screened a genome-wide shRNA library. Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and validate its function in telomere-induced, replicative, and oncogene-ind...

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Detalles Bibliográficos
Autores principales: Innes, Andrew J., Sun, Bin, Wagner, Verena, Brookes, Sharon, McHugh, Domhnall, Pombo, Joaquim, Porreca, Rosa María, Dharmalingam, Gopuraja, Vernia, Santiago, Zuber, Johannes, Vannier, Jean-Baptiste, García-Escudero, Ramón, Gil, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919420/
https://www.ncbi.nlm.nih.gov/pubmed/33602872
http://dx.doi.org/10.1101/gad.343269.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919420/
https://www.ncbi.nlm.nih.gov/pubmed/33602872
http://dx.doi.org/10.1101/gad.343269.120

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