Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and is associated with aging-related diseases. However, it is unclear how mtDNA-CN measured in blood can reflect diseases that primarily manifest in other tissues. Using the Genotype-Tissue Expression Project, we interrog...

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Detalles Bibliográficos
Autores principales: Yang, Stephanie Y., Castellani, Christina A., Longchamps, Ryan J., Pillalamarri, Vamsee K., O'Rourke, Brian, Guallar, Eliseo, Arking, Dan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919448/
https://www.ncbi.nlm.nih.gov/pubmed/33441415
http://dx.doi.org/10.1101/gr.269381.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919448/
https://www.ncbi.nlm.nih.gov/pubmed/33441415
http://dx.doi.org/10.1101/gr.269381.120

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