Effect of C-terminus Conjugation via Different Conjugation Chemistries on In Vivo Activity of Albumin-Conjugated Recombinant GLP-1

Glucagon-like peptide-1 (GLP-1) is a peptide hormone with tremendous therapeutic potential for treating type 2 diabetes mellitus. However, the short half-life of its native form is a significant drawback. We previously prolonged the plasma half-life of GLP-1 via site-specific conjugation of human se...

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Detalles Bibliográficos
Autores principales: Park, Junyong, Bak, Mijeong, Min, Kiyoon, Kim, Hyun-Woo, Cho, Jeong-Haeng, Tae, Giyoong, Kwon, Inchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919490/
https://www.ncbi.nlm.nih.gov/pubmed/33672039
http://dx.doi.org/10.3390/pharmaceutics13020263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919490/
https://www.ncbi.nlm.nih.gov/pubmed/33672039
http://dx.doi.org/10.3390/pharmaceutics13020263

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