N-Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation

Substituted N-phenyl cinnamamide derivatives were designed and synthesized to confirm activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway by the electronic effect on beta-position of Michael acceptor according to introducing the R(1) and R(2) group. Compounds were screened using...

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Detalles Bibliográficos
Autores principales: Kim, Sou Hyun, Kim, Minwoo, Kwon, Doyoung, Pyo, Jae Sung, Kim, Joo Hyun, Kwak, Jae-Hwan, Jung, Young-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919495/
https://www.ncbi.nlm.nih.gov/pubmed/33672046
http://dx.doi.org/10.3390/molecules26041027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919495/
https://www.ncbi.nlm.nih.gov/pubmed/33672046
http://dx.doi.org/10.3390/molecules26041027

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