Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection. Here, we present evidence for the transcriptional regulation of SARS-CoV-2 host cell receptor ACE2 and TMPRSS2 by androgen in mouse and human cells. Additi...

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Detalles Bibliográficos
Autores principales: Deng, Qu, Rasool, Reyaz ur, Russell, Ronnie M., Natesan, Ramakrishnan, Asangani, Irfan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919514/
https://www.ncbi.nlm.nih.gov/pubmed/33681723
http://dx.doi.org/10.1016/j.isci.2021.102254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919514/
https://www.ncbi.nlm.nih.gov/pubmed/33681723
http://dx.doi.org/10.1016/j.isci.2021.102254

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