TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism

BACKGROUND: Transforming growth factor-β (TGFβ) is emerging as a promising target for cancer therapy, given its ability to promote progression of advanced tumors and to suppress anti-tumor immune responses. However, TGFβ also plays multiple roles in normal tissues, particularly during organogenesis,...

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Detalles Bibliográficos
Autores principales: Canè, Stefania, Van Snick, Jacques, Uyttenhove, Catherine, Pilotte, Luc, Van den Eynde, Benoit J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919595/
https://www.ncbi.nlm.nih.gov/pubmed/33637600
http://dx.doi.org/10.1136/jitc-2020-001798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919595/
https://www.ncbi.nlm.nih.gov/pubmed/33637600
http://dx.doi.org/10.1136/jitc-2020-001798

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