The E protein-TCF1 axis controls γδ T cell development and effector fate

TCF1 plays a critical role in T lineage commitment and the development of αβ lineage T cells, but its role in γδ T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory elemen...

Descripción completa

Detalles Bibliográficos
Autores principales: Fahl, Shawn P., Contreras, Alejandra V., Verma, Anjali, Qiu, Xiang, Harly, Christelle, Radtke, Freddy, Zúñiga-Pflücker, Juan Carlos, Murre, Cornelis, Xue, Hai-Hui, Sen, Jyoti Misra, Wiest, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919611/
https://www.ncbi.nlm.nih.gov/pubmed/33535043
http://dx.doi.org/10.1016/j.celrep.2021.108716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919611/
https://www.ncbi.nlm.nih.gov/pubmed/33535043
http://dx.doi.org/10.1016/j.celrep.2021.108716

Ejemplares similares