BTK Inhibition Reverses MDSC-Mediated Immunosuppression and Enhances Response to Anti-PDL1 Therapy in Neuroblastoma

SIMPLE SUMMARY: Neuroblastoma (NB) is the most common pediatric malignancy, and patients with the high-risk disease show a worse prognosis despite advanced treatments, including immunotherapy. Myeloid-derived suppressor cells (MDSC) frequently accumulate in NB tumors, where they induce immunosuppres...

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Detalles Bibliográficos
Autores principales: Ishfaq, Mehreen, Pham, Timothy, Beaman, Cooper, Tamayo, Pablo, Yu, Alice L., Joshi, Shweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919651/
https://www.ncbi.nlm.nih.gov/pubmed/33669187
http://dx.doi.org/10.3390/cancers13040817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919651/
https://www.ncbi.nlm.nih.gov/pubmed/33669187
http://dx.doi.org/10.3390/cancers13040817

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