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Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions

[Image: see text] The activation barriers ΔG(⧧) for k(cat)/K(m) for the reactions of whole substrates catalyzed by 6-phosphogluconate dehydrogenase, glucose 6-phosphate dehydrogenase, and glucose 6-phosphate isomerase are reduced by 11–13 kcal/mol by interactions between the protein and the substrat...

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Detalles Bibliográficos
Autores principales: Fernandez, Patrick L., Nagorski, Richard W., Cristobal, Judith R., Amyes, Tina L., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919737/
https://www.ncbi.nlm.nih.gov/pubmed/33560827
http://dx.doi.org/10.1021/jacs.0c13423