Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

The accumulation of damaged mitochondria due to insufficient autophagy has been implicated in the pathophysiology of skeletal muscle aging. Ulk1 is an autophagy-related kinase that initiates autophagosome assembly and may also play a role in autophagosome degradation (i.e., autophagy flux), but the...

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Detalles Bibliográficos
Autores principales: Nichenko, Anna S., Sorensen, Jacob R., Southern, W. Michael, Qualls, Anita E., Schifino, Albino G., McFaline-Figueroa, Jennifer, Blum, Jamie E., Tehrani, Kayvan F., Yin, Hang, Mortensen, Luke J., Thalacker-Mercer, Anna E., Greising, Sarah M., Call, Jarrod A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919824/
https://www.ncbi.nlm.nih.gov/pubmed/33669246
http://dx.doi.org/10.3390/ijms22041937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919824/
https://www.ncbi.nlm.nih.gov/pubmed/33669246
http://dx.doi.org/10.3390/ijms22041937

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