Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anticancer therapeutic antibodi...

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Detalles Bibliográficos
Autores principales: Larsen, Mads Delbo, de Graaf, Erik L., Sonneveld, Myrthe E., Plomp, H. Rosina, Nouta, Jan, Hoepel, Willianne, Chen, Hung-Jen, Linty, Federica, Visser, Remco, Brinkhaus, Maximilian, Šuštić, Tonći, de Taeye, Steven W., Bentlage, Arthur E. H., Toivonen, Suvi, Koeleman, Carolien A. M., Sainio, Susanna, Kootstra, Neeltje A., Brouwer, Philip J. M., Geyer, Chiara Elisabeth, Derksen, Ninotska I. L., Wolbink, Gertjan, de Winther, Menno, Sanders, Rogier W., van Gils, Marit J., de Bruin, Sanne, Vlaar, Alexander P. J., Rispens, Theo, den Dunnen, Jeroen, Zaaijer, Hans L., Wuhrer, Manfred, Ellen van der Schoot, C., Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919849/
https://www.ncbi.nlm.nih.gov/pubmed/33361116
http://dx.doi.org/10.1126/science.abc8378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919849/
https://www.ncbi.nlm.nih.gov/pubmed/33361116
http://dx.doi.org/10.1126/science.abc8378

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