DNA Methylation, Mechanisms of FMR1 Inactivation and Therapeutic Perspectives for Fragile X Syndrome

Among the inherited causes of intellectual disability and autism, Fragile X syndrome (FXS) is the most frequent form, for which there is currently no cure. In most FXS patients, the FMR1 gene is epigenetically inactivated following the expansion over 200 triplets of a CGG repeat (FM: full mutation)....

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Detalles Bibliográficos
Autores principales: Nobile, Veronica, Pucci, Cecilia, Chiurazzi, Pietro, Neri, Giovanni, Tabolacci, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920310/
https://www.ncbi.nlm.nih.gov/pubmed/33669384
http://dx.doi.org/10.3390/biom11020296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920310/
https://www.ncbi.nlm.nih.gov/pubmed/33669384
http://dx.doi.org/10.3390/biom11020296

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