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Marek’s disease virus U(S)3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis

Marek’s disease virus (MDV) is a potent oncogenic alphaherpesvirus that elicits a rapid onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV-1), GaHV-3 (MDV-2) and MeHV-1 (HVT), have been identified and all encode a U(S)3 protein kinase. MDV-1 U(S)3 is important fo...

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Detalles Bibliográficos
Autores principales: Liao, Yifei, Lupiani, Blanca, AI-Mahmood, Mohammad, Reddy, Sanjay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920345/
https://www.ncbi.nlm.nih.gov/pubmed/33596269
http://dx.doi.org/10.1371/journal.ppat.1009307