Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment

The clinical use of cytotoxic agents is plagued by systemic toxicity. We report a novel approach that seeks to design a “combi-molecule” to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor microenvironmen...

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Detalles Bibliográficos
Autores principales: Larroque-Lombard, Anne-Laure, Chatelut, Etienne, Delord, Jean-Pierre, Imbs, Diane-Charlotte, Rochaix, Philippe, Jean-Claude, Bertrand, Allal, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920489/
https://www.ncbi.nlm.nih.gov/pubmed/33669415
http://dx.doi.org/10.3390/ph14020160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920489/
https://www.ncbi.nlm.nih.gov/pubmed/33669415
http://dx.doi.org/10.3390/ph14020160

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