The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling

BACKGROUND: Metabolic reprogramming is a common feature in cancer, and it is critical to facilitate cancer cell growth. Isocitrate Dehydrogenase 1/2 (IDH1 and IDH2) mutations (IDHmut) are the most common genetic alteration in glioma grade II and III and secondary glioblastoma and these mutations inc...

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Detalles Bibliográficos
Autores principales: Yamashita, Alex Shimura, da Costa Rosa, Marina, Stumpo, Vittorio, Rais, Rana, Slusher, Barbara S, Riggins, Gregory J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920530/
https://www.ncbi.nlm.nih.gov/pubmed/33681764
http://dx.doi.org/10.1093/noajnl/vdaa149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920530/
https://www.ncbi.nlm.nih.gov/pubmed/33681764
http://dx.doi.org/10.1093/noajnl/vdaa149

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