Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family of regulatory subunits of key cellular phosphatase...

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Detalles Bibliográficos
Autores principales: Marelli, Sara, Williamson, James C, Protasio, Anna V, Naamati, Adi, Greenwood, Edward JD, Deane, Janet E, Lehner, Paul J, Matheson, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920553/
https://www.ncbi.nlm.nih.gov/pubmed/32292164
http://dx.doi.org/10.7554/eLife.53036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920553/
https://www.ncbi.nlm.nih.gov/pubmed/32292164
http://dx.doi.org/10.7554/eLife.53036

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