High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's anticancer effects remains elusive. Using clin...

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Detalles Bibliográficos
Autores principales: Pingali, Pavani, Wu, Y. Jeffrey, Boothello, Rio, Sharon, Chetna, Li, Howard, Sistla, Srinivas, Sankaranarayanan, Nehru Viji, Desai, Umesh R., Le, Anh T., Doebele, Robert C., Muldoon, Leslie L., Patel, Bhaumik B., Neuwelt, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920811/
https://www.ncbi.nlm.nih.gov/pubmed/33640759
http://dx.doi.org/10.1016/j.neo.2021.02.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920811/
https://www.ncbi.nlm.nih.gov/pubmed/33640759
http://dx.doi.org/10.1016/j.neo.2021.02.001

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