Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb(2) format where a set of mutated amino acid residues in the C(H)3 domains enables a high-affi...

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Detalles Bibliográficos
Autores principales: Benedetti, Filippo, Stracke, Florian, Stadlmayr, Gerhard, Stadlbauer, Katharina, Rüker, Florian, Wozniak-Knopp, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920882/
https://www.ncbi.nlm.nih.gov/pubmed/33718630
http://dx.doi.org/10.1016/j.bbrep.2021.100959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920882/
https://www.ncbi.nlm.nih.gov/pubmed/33718630
http://dx.doi.org/10.1016/j.bbrep.2021.100959

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