Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance

Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma and intrahepatic cholangiocarcinoma. We begin this re...

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Detalles Bibliográficos
Autores principales: Krook, Melanie A., Reeser, Julie W., Ernst, Gabrielle, Barker, Hannah, Wilberding, Max, Li, Gary, Chen, Hui-Zi, Roychowdhury, Sameek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921129/
https://www.ncbi.nlm.nih.gov/pubmed/33268819
http://dx.doi.org/10.1038/s41416-020-01157-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921129/
https://www.ncbi.nlm.nih.gov/pubmed/33268819
http://dx.doi.org/10.1038/s41416-020-01157-0

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