Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Rheumatoid arthritis (RA) is an autoimmune disease. Fibroblast-like synoviocytes (FLS) serve a major role in synovial hyperplasia and inflammation in RA. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, shows promising therapeutic effects for RA and is now in phase II clinical trial...

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Detalles Bibliográficos
Autores principales: Zhou, Xinpeng, Xie, Duoli, Huang, Jie, Lu, Aiping, Wang, Rongsheng, Jin, Yehua, Zhang, Runrun, Chang, Cen, Xu, Lingxia, Xu, Linshuai, Fan, Junyu, Liang, Chao, He, Dongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921149/
https://www.ncbi.nlm.nih.gov/pubmed/33664742
http://dx.doi.org/10.3389/fimmu.2021.605616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921149/
https://www.ncbi.nlm.nih.gov/pubmed/33664742
http://dx.doi.org/10.3389/fimmu.2021.605616

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