The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response

The therapeutic landscape of drugs targeting the DNA damage response (DDR) is rapidly expanding; however, an urgent unmet need remains for validated predictive biomarkers of response. SLFN11 has emerged as a promising predictor of sensitivity to DNA-damaging chemotherapies, and recently, been associ...

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Detalles Bibliográficos
Autores principales: Coleman, Niamh, Zhang, Bingnan, Byers, Lauren A., Yap, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921443/
https://www.ncbi.nlm.nih.gov/pubmed/33328609
http://dx.doi.org/10.1038/s41416-020-01202-y
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author Coleman, Niamh
Zhang, Bingnan
Byers, Lauren A.
Yap, Timothy A.
author_facet Coleman, Niamh
Zhang, Bingnan
Byers, Lauren A.
Yap, Timothy A.
author_sort Coleman, Niamh
collection PubMed
description The therapeutic landscape of drugs targeting the DNA damage response (DDR) is rapidly expanding; however, an urgent unmet need remains for validated predictive biomarkers of response. SLFN11 has emerged as a promising predictor of sensitivity to DNA-damaging chemotherapies, and recently, been associated with sensitivity to PARP inhibition. We discuss its use as a predictive biomarker of response for targeting the DDR.
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spelling pubmed-79214432021-12-16 The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response Coleman, Niamh Zhang, Bingnan Byers, Lauren A. Yap, Timothy A. Br J Cancer Editorial The therapeutic landscape of drugs targeting the DNA damage response (DDR) is rapidly expanding; however, an urgent unmet need remains for validated predictive biomarkers of response. SLFN11 has emerged as a promising predictor of sensitivity to DNA-damaging chemotherapies, and recently, been associated with sensitivity to PARP inhibition. We discuss its use as a predictive biomarker of response for targeting the DDR. Nature Publishing Group UK 2020-12-16 2021-03-02 /pmc/articles/PMC7921443/ /pubmed/33328609 http://dx.doi.org/10.1038/s41416-020-01202-y Text en © Cancer Research UK 2020 https://creativecommons.org/licenses/by/4.0/ Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Editorial
Coleman, Niamh
Zhang, Bingnan
Byers, Lauren A.
Yap, Timothy A.
The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title_full The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title_fullStr The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title_full_unstemmed The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title_short The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response
title_sort role of schlafen 11 (slfn11) as a predictive biomarker for targeting the dna damage response
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921443/
https://www.ncbi.nlm.nih.gov/pubmed/33328609
http://dx.doi.org/10.1038/s41416-020-01202-y
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