The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

BACKGROUND: The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB downregulation induced fat accumulation and the...

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Detalles Bibliográficos
Autores principales: Panera, Nadia, Meroni, Marica, Longo, Miriam, Crudele, Annalisa, Valenti, Luca, Bellacchio, Emanuele, Miele, Luca, D'Oria, Valentina, Paolini, Erika, Maggioni, Marco, Fracanzani, Anna Ludovica, Alisi, Anna, Dongiovanni, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921469/
https://www.ncbi.nlm.nih.gov/pubmed/33640795
http://dx.doi.org/10.1016/j.ebiom.2021.103249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921469/
https://www.ncbi.nlm.nih.gov/pubmed/33640795
http://dx.doi.org/10.1016/j.ebiom.2021.103249

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