Cargando…

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

BACKGROUND: The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB downregulation induced fat accumulation and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panera, Nadia, Meroni, Marica, Longo, Miriam, Crudele, Annalisa, Valenti, Luca, Bellacchio, Emanuele, Miele, Luca, D'Oria, Valentina, Paolini, Erika, Maggioni, Marco, Fracanzani, Anna Ludovica, Alisi, Anna, Dongiovanni, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921469/ https://www.ncbi.nlm.nih.gov/pubmed/33640795 http://dx.doi.org/10.1016/j.ebiom.2021.103249

Ejemplares similares

MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD
por: Meroni, Marica, et al.
Publicado: (2020)

The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients
por: Meroni, Marica, et al.
Publicado: (2021)

mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance
por: Meroni, Marica, et al.
Publicado: (2019)

The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
por: Mosca, Antonella, et al.
Publicado: (2022)

TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
por: Longo, Miriam, et al.
Publicado: (2021)

The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value
por: Paolini, Erika, et al.
Publicado: (2023)

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study
por: Dongiovanni, Paola, et al.
Publicado: (2010)

α-Lipoic Acid Improves Hepatic Metabolic Dysfunctions in Acute Intermittent Porphyria: A Proof-of-Concept Study
por: Longo, Miriam, et al.
Publicado: (2021)

miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis
por: Dongiovanni, Paola, et al.
Publicado: (2018)

Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
por: Dongiovanni, Paola, et al.
Publicado: (2021)

Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma
por: Panera, Nadia, et al.
Publicado: (2017)

Expanding the phenotypic spectrum of non-alcoholic fatty liver disease and hypertriglyceridemia
por: Meroni, Marica, et al.
Publicado: (2022)

Circulating histone signature of human lean metabolic-associated fatty liver disease (MAFLD)
por: Buzova, Diana, et al.
Publicado: (2020)

PD-1/PD-L1 Immuno-Mediated Therapy in NAFLD: Advantages and Obstacles in the Treatment of Advanced Disease
por: Lombardi, Rosa, et al.
Publicado: (2022)

Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies
por: Cespiati, Annalisa, et al.
Publicado: (2022)

An Overview of Hepatocellular Carcinoma Surveillance Focusing on Non-Cirrhotic NAFLD Patients: A Challenge for Physicians
por: Cespiati, Annalisa, et al.
Publicado: (2023)

Genetics, epigenetics and transgenerational transmission of obesity in children
por: Panera, Nadia, et al.
Publicado: (2022)

Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
por: Meroni, Marica, et al.
Publicado: (2021)

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes
por: Meroni, Marica, et al.
Publicado: (2020)

The Number of Liver Galectin-3 Positive Cells Is Dually Correlated with NAFLD Severity in Children
por: de Oliveira, Felipe Leite, et al.
Publicado: (2019)

Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC
por: Longo, Miriam, et al.
Publicado: (2021)

Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution
por: Longo, Miriam, et al.
Publicado: (2022)

Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease
por: Dongiovanni, Paola, et al.
Publicado: (2018)

High Fat Diet Subverts Hepatocellular Iron Uptake Determining Dysmetabolic Iron Overload
por: Dongiovanni, Paola, et al.
Publicado: (2015)

Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker
por: Baselli, Guido Alessandro, et al.
Publicado: (2020)

Plasma Levels of Homocysteine and Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage
por: Pastore, Anna, et al.
Publicado: (2014)

KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism
por: Xu, Cheng, et al.
Publicado: (2017)

KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction
por: Cortes‐Araya, Yennifer, et al.
Publicado: (2022)

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
por: Agrawal, Archita, et al.
Publicado: (2018)

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes
por: Nason, Shelly R., et al.
Publicado: (2021)

PNPLA3 rs738409 Genetic Variant Inversely Correlates with Platelet Count, Thereby Affecting the Performance of Noninvasive Scores of Hepatic Fibrosis
por: Meroni, Marica, et al.
Publicado: (2023)

The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
por: Panera, Nadia, et al.
Publicado: (2020)

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores
por: Bianco, Cristiana, et al.
Publicado: (2021)

KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese
por: Ji, Fang, et al.
Publicado: (2019)

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease
por: Mosca, Antonella, et al.
Publicado: (2022)

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2
por: Gnani, Daniela, et al.
Publicado: (2017)

PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease
por: Tortora, Raffaella, et al.
Publicado: (2018)

Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children
por: Alisi, Anna, et al.
Publicado: (2011)

Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis
por: Alisi, Anna, et al.
Publicado: (2012)

The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease
por: Valenti, Luca, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k0dsdo8gl7di90lt9oavmo1dbg