Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold. We then conducted biological screening using hypoxia inducible factor (HIF)-1- and unfo...

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Detalles Bibliográficos
Autores principales: Sakai, Takayuki, Matsuo, Yoshiyuki, Okuda, Kensuke, Hirota, Kiichi, Tsuji, Mieko, Hirayama, Tasuku, Nagasawa, Hideko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921556/
https://www.ncbi.nlm.nih.gov/pubmed/33649449
http://dx.doi.org/10.1038/s41598-021-83708-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921556/
https://www.ncbi.nlm.nih.gov/pubmed/33649449
http://dx.doi.org/10.1038/s41598-021-83708-w

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