Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer

BACKGROUND: SPOP, an E3 ubiquitin ligase adaptor, can act either as a tumour suppressor or a tumour promoter. In prostate cancer (PCa), it inhibits tumorigenesis by degrading several oncogenic substrates. SPOP is the most altered gene in PCa (~15%), which renders it ineffective, promoting cancer. Th...

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Detalles Bibliográficos
Autores principales: Nikhil, Kumar, Haymour, Hanan S., Kamra, Mohini, Shah, Kavita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921662/
https://www.ncbi.nlm.nih.gov/pubmed/33311589
http://dx.doi.org/10.1038/s41416-020-01197-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921662/
https://www.ncbi.nlm.nih.gov/pubmed/33311589
http://dx.doi.org/10.1038/s41416-020-01197-6

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