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Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
BACKGROUND: SPOP, an E3 ubiquitin ligase adaptor, can act either as a tumour suppressor or a tumour promoter. In prostate cancer (PCa), it inhibits tumorigenesis by degrading several oncogenic substrates. SPOP is the most altered gene in PCa (~15%), which renders it ineffective, promoting cancer. Th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921662/ https://www.ncbi.nlm.nih.gov/pubmed/33311589 http://dx.doi.org/10.1038/s41416-020-01197-6 |