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Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats
Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) proteins, on the development of hyperuricemic nephr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921804/ https://www.ncbi.nlm.nih.gov/pubmed/33664670 http://dx.doi.org/10.3389/fphar.2021.636154 |