Identification and Characterization of Mortaparib(Plus)—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

SIMPLE SUMMARY: Functional inactivation of tumour suppressor protein p53 is frequently found in a large variety of cancers. One of the mechanisms by which p53 is inactivated is through its interaction with mortalin protein that inhibits its translocation, and hence the function, in the nucleus. Abro...

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Detalles Bibliográficos
Autores principales: Sari, Anissa Nofita, Elwakeel, Ahmed, Dhanjal, Jaspreet Kaur, Kumar, Vipul, Sundar, Durai, Kaul, Sunil C., Wadhwa, Renu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921971/
https://www.ncbi.nlm.nih.gov/pubmed/33671256
http://dx.doi.org/10.3390/cancers13040835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921971/
https://www.ncbi.nlm.nih.gov/pubmed/33671256
http://dx.doi.org/10.3390/cancers13040835

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