Identification of Somatic Structural Variants in Solid Tumors by Optical Genome Mapping

Genomic structural variants comprise a significant fraction of somatic mutations driving cancer onset and progression. However, such variants are not readily revealed by standard next-generation sequencing. Optical genome mapping (OGM) surpasses short-read sequencing in detecting large (>500 bp)...

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Detalles Bibliográficos
Autores principales: Goldrich, David Y., LaBarge, Brandon, Chartrand, Scott, Zhang, Lijun, Sadowski, Henry B., Zhang, Yang, Pham, Khoa, Way, Hannah, Lai, Chi-Yu Jill, Pang, Andy Wing Chun, Clifford, Benjamin, Hastie, Alex R., Oldakowski, Mark, Goldenberg, David, Broach, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921992/
https://www.ncbi.nlm.nih.gov/pubmed/33670576
http://dx.doi.org/10.3390/jpm11020142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921992/
https://www.ncbi.nlm.nih.gov/pubmed/33670576
http://dx.doi.org/10.3390/jpm11020142

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