Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other hand, its metabolism can be affected by vario...

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Detalles Bibliográficos
Autores principales: Fuhr, Laura Maria, Marok, Fatima Zahra, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922031/
https://www.ncbi.nlm.nih.gov/pubmed/33671323
http://dx.doi.org/10.3390/pharmaceutics13020270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922031/
https://www.ncbi.nlm.nih.gov/pubmed/33671323
http://dx.doi.org/10.3390/pharmaceutics13020270

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