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Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
Bone metastases frequently occur in breast cancer patients and lack appropriate treatment options. Hence, understanding the molecular mechanisms involved in the multistep process of breast cancer bone metastasis and tumor-induced osteolysis is of paramount interest. The serine/threonine kinase AKT p...
Autores principales: | Hinz, Nico, Baranowsky, Anke, Horn, Michael, Kriegs, Malte, Sibbertsen, Freya, Smit, Daniel J., Clezardin, Philippe, Lange, Tobias, Schinke, Thorsten, Jücker, Manfred |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922044/ https://www.ncbi.nlm.nih.gov/pubmed/33670586 http://dx.doi.org/10.3390/cells10020430 |
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