Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase

Itaconate is a small molecule metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes. The metabolic consequences of itaconate in cells are diverse and contribute to its regulatory function. Here, we have applied...

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Detalles Bibliográficos
Autores principales: Cordes, Thekla, Metallo, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922098/
https://www.ncbi.nlm.nih.gov/pubmed/33670656
http://dx.doi.org/10.3390/metabo11020117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922098/
https://www.ncbi.nlm.nih.gov/pubmed/33670656
http://dx.doi.org/10.3390/metabo11020117

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