Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FRα. an In Silico Insight

Folate receptor alpha (FRα) is known as a biological marker for many cancers due to its overexpression in cancerous epithelial tissue. The folic acid (FA) binding affinity to the FRα active site provides a basis for designing more specific targets for FRα. Heterocyclic rings have been shown to inter...

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Detalles Bibliográficos
Autores principales: Al-Thiabat, Mohammad G., Saqallah, Fadi G., Gazzali, Amirah Mohd, Mohtar, Noratiqah, Yap, Beow Keat, Choong, Yee Siew, Wahab, Habibah A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922218/
https://www.ncbi.nlm.nih.gov/pubmed/33670773
http://dx.doi.org/10.3390/molecules26041079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922218/
https://www.ncbi.nlm.nih.gov/pubmed/33670773
http://dx.doi.org/10.3390/molecules26041079

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