BECN1 and BRCA1 Deficiency Sensitizes Ovarian Cancer to Platinum Therapy and Confers Better Prognosis

Background: BRCA1, BECN1 and TP53 are three tumor suppressor genes located on chromosome 17 and frequently found deleted, silenced, or mutated in many cancers. These genes are involved in autophagy, apoptosis, and drug resistance in ovarian cancer. Haploinsufficiency or loss-of-function of either TP...

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Detalles Bibliográficos
Autores principales: Salwa, Amreen, Ferraresi, Alessandra, Chinthakindi, Menaka, Vallino, Letizia, Vidoni, Chiara, Dhanasekaran, Danny N., Isidoro, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922320/
https://www.ncbi.nlm.nih.gov/pubmed/33670664
http://dx.doi.org/10.3390/biomedicines9020207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922320/
https://www.ncbi.nlm.nih.gov/pubmed/33670664
http://dx.doi.org/10.3390/biomedicines9020207

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