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The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation
The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaen...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922349/ https://www.ncbi.nlm.nih.gov/pubmed/33671288 http://dx.doi.org/10.3390/nu13020651 |
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author | Reiner, Martin F. Baumgartner, Philipp Wiencierz, Andrea Coslovsky, Michael Bonetti, Nicole R. Filipovic, Mark G. Montrasio, Giulia Aeschbacher, Stefanie Rodondi, Nicolas Baretella, Oliver Kühne, Michael Moschovitis, Giorgio Meyre, Pascal Bonati, Leo H. Lüscher, Thomas F. Camici, Giovanni G. Osswald, Stefan Conen, David Beer, Jürg H. |
author_facet | Reiner, Martin F. Baumgartner, Philipp Wiencierz, Andrea Coslovsky, Michael Bonetti, Nicole R. Filipovic, Mark G. Montrasio, Giulia Aeschbacher, Stefanie Rodondi, Nicolas Baretella, Oliver Kühne, Michael Moschovitis, Giorgio Meyre, Pascal Bonati, Leo H. Lüscher, Thomas F. Camici, Giovanni G. Osswald, Stefan Conen, David Beer, Jürg H. |
author_sort | Reiner, Martin F. |
collection | PubMed |
description | The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha-linolenic acid (ALA) were determined by gas chromatography in 1657 AF patients from the Swiss Atrial Fibrillation study. All patients underwent brain MRI to detect ischemic brain infarcts, classified as large noncortical or cortical infarcts (LNCCIs); markers of small vessel disease, classified as small noncortical infarcts (SNCIs), number of microbleeds, and white matter lesion (WML) volumes. Individual and total n-3 FAs (EPA + DHA + DPA + ALA) were correlated with LNCCIs and SNCIs using logistic regression, with numbers of microbleeds using a hurdle model, and WML volumes using linear regression. LNCCIs were detected in 372 patients (22.5%). EPA correlated inversely with the prevalence of LNCCIs (odds ratio [OR] 0.51 per increase of 1 percentage point EPA, 95% confidence interval [CI] 0.29–0.90). DPA correlated with a higher LNCCI prevalence (OR 2.48, 95%CI 1.49–4.13). No associations with LNCCIs were found for DHA, ALA, and total n-3 FAs. Neither individual nor total n-3 FAs correlated with markers of small vessel disease. In conclusion, EPA correlates inversely with the prevalence of ischemic brain infarcts, but not with markers of small vessel disease in patients with AF. |
format | Online Article Text |
id | pubmed-7922349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79223492021-03-03 The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation Reiner, Martin F. Baumgartner, Philipp Wiencierz, Andrea Coslovsky, Michael Bonetti, Nicole R. Filipovic, Mark G. Montrasio, Giulia Aeschbacher, Stefanie Rodondi, Nicolas Baretella, Oliver Kühne, Michael Moschovitis, Giorgio Meyre, Pascal Bonati, Leo H. Lüscher, Thomas F. Camici, Giovanni G. Osswald, Stefan Conen, David Beer, Jürg H. Nutrients Article The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha-linolenic acid (ALA) were determined by gas chromatography in 1657 AF patients from the Swiss Atrial Fibrillation study. All patients underwent brain MRI to detect ischemic brain infarcts, classified as large noncortical or cortical infarcts (LNCCIs); markers of small vessel disease, classified as small noncortical infarcts (SNCIs), number of microbleeds, and white matter lesion (WML) volumes. Individual and total n-3 FAs (EPA + DHA + DPA + ALA) were correlated with LNCCIs and SNCIs using logistic regression, with numbers of microbleeds using a hurdle model, and WML volumes using linear regression. LNCCIs were detected in 372 patients (22.5%). EPA correlated inversely with the prevalence of LNCCIs (odds ratio [OR] 0.51 per increase of 1 percentage point EPA, 95% confidence interval [CI] 0.29–0.90). DPA correlated with a higher LNCCI prevalence (OR 2.48, 95%CI 1.49–4.13). No associations with LNCCIs were found for DHA, ALA, and total n-3 FAs. Neither individual nor total n-3 FAs correlated with markers of small vessel disease. In conclusion, EPA correlates inversely with the prevalence of ischemic brain infarcts, but not with markers of small vessel disease in patients with AF. MDPI 2021-02-17 /pmc/articles/PMC7922349/ /pubmed/33671288 http://dx.doi.org/10.3390/nu13020651 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Reiner, Martin F. Baumgartner, Philipp Wiencierz, Andrea Coslovsky, Michael Bonetti, Nicole R. Filipovic, Mark G. Montrasio, Giulia Aeschbacher, Stefanie Rodondi, Nicolas Baretella, Oliver Kühne, Michael Moschovitis, Giorgio Meyre, Pascal Bonati, Leo H. Lüscher, Thomas F. Camici, Giovanni G. Osswald, Stefan Conen, David Beer, Jürg H. The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title | The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title_full | The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title_fullStr | The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title_full_unstemmed | The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title_short | The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation |
title_sort | omega-3 fatty acid eicosapentaenoic acid (epa) correlates inversely with ischemic brain infarcts in patients with atrial fibrillation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922349/ https://www.ncbi.nlm.nih.gov/pubmed/33671288 http://dx.doi.org/10.3390/nu13020651 |
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