De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans

Defects in the mitochondrial genome (mitochondrial DNA (mtDNA)) are associated with both congenital and acquired disorders in humans. Nuclear-encoded DNA polymerase subunit gamma (POLG) plays an important role in mtDNA replication, and proofreading and mutations in POLG have been linked with increas...

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Detalles Bibliográficos
Autores principales: Lee, Yeonmi, Kim, Taeho, Lee, Miju, So, Seongjun, Karagozlu, Mustafa Zafer, Seo, Go Hun, Choi, In Hee, Lee, Peter C. W., Kim, Chong-Jai, Kang, Eunju, Lee, Beom Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922481/
https://www.ncbi.nlm.nih.gov/pubmed/33671400
http://dx.doi.org/10.3390/genes12020284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922481/
https://www.ncbi.nlm.nih.gov/pubmed/33671400
http://dx.doi.org/10.3390/genes12020284

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