Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl fumarate (DMF) is an oral agent for relapsing-remitting multiple sclerosis (RRMS). In this study, we investigated the therapeutic mechanism of DMF using experimental autoimmune encephalomyelitis (EAE). DMF treatment decreased the proliferation of T cells and the production of IL-17A and GM-...

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Detalles Bibliográficos
Autores principales: Yadav, Sudhir K., Ito, Naoko, Soin, Devika, Ito, Kouichi, Dhib-Jalbut, Suhayl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922578/
https://www.ncbi.nlm.nih.gov/pubmed/33669652
http://dx.doi.org/10.3390/jcm10040857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922578/
https://www.ncbi.nlm.nih.gov/pubmed/33669652
http://dx.doi.org/10.3390/jcm10040857

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