Cargando…

Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl fumarate (DMF) is an oral agent for relapsing-remitting multiple sclerosis (RRMS). In this study, we investigated the therapeutic mechanism of DMF using experimental autoimmune encephalomyelitis (EAE). DMF treatment decreased the proliferation of T cells and the production of IL-17A and GM-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yadav, Sudhir K., Ito, Naoko, Soin, Devika, Ito, Kouichi, Dhib-Jalbut, Suhayl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922578/ https://www.ncbi.nlm.nih.gov/pubmed/33669652 http://dx.doi.org/10.3390/jcm10040857

Ejemplares similares

Interaction of the Gut Microbiome and Immunity in Multiple Sclerosis: Impact of Diet and Immune Therapy
por: Yadav, Sudhir Kumar, et al.
Publicado: (2023)

Effect of switching glatiramer acetate formulation from 20 mg daily to 40 mg three times weekly on immune function in multiple sclerosis
por: Ito, Kouichi, et al.
Publicado: (2021)

Early Treatment with Anti-VLA-4 mAb Can Prevent the Infiltration and/or Development of Pathogenic CD11b(+)CD4(+) T Cells in the CNS during Progressive EAE
por: Mindur, John E., et al.
Publicado: (2014)

Surface Layer Protein A Expressed in Clostridioides difficile DJNS06-36 Possesses an Encephalitogenic Mimotope of Myelin Basic Protein
por: Mindur, John E., et al.
Publicado: (2020)

Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis
por: Yadav, Sudhir K., et al.
Publicado: (2022)

Potential Risks and Benefits of Multiple Sclerosis Immune Therapies in the COVID-19 Era: Clinical and Immunological Perspectives
por: Bhise, Vikram, et al.
Publicado: (2021)

Multiple sclerosis: Possible immunological mechanisms()
por: McFarland, Henry F., et al.
Publicado: (1989)

Mechanism of measles virus failure to activate NF-κB in neuronal cells
por: Fang, Yu -Yan, et al.
Publicado: (2001)

Interleukin-1β decreases HLA class II expression on a glioblastoma multiforme cell line
por: Cowan, Elliot P., et al.
Publicado: (1991)

Adult human glial cells can present target antigens to HLA-restricted cytotoxic T-cells
por: Dhib-Jalbut, Suhayl, et al.
Publicado: (1990)

Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination
por: Cerina, Manuela, et al.
Publicado: (2018)

Monthly triple-dose gadolinium administration: potential associations with leukopenia, hypophosphatemia, and bone marrow T1 hyperintensity
por: Chen, Daniel, et al.
Publicado: (2022)

Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection
por: Pitarokoili, Kalliopi, et al.
Publicado: (2015)

The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1
por: Lin, Shao Xia, et al.
Publicado: (2011)

Correction: Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection
Publicado: (2016)

Dimethyl fumarate for ischemic stroke
por: Kunze, Reiner
Publicado: (2017)

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice
por: Yao, Yang, et al.
Publicado: (2016)

Effects of dimethyl fumarate on neuroprotection and immunomodulation
por: Albrecht, Philipp, et al.
Publicado: (2012)

Dimethyl fumarate mitigates optic neuritis
por: Zyla, Katarzyna, et al.
Publicado: (2019)

Dimethyl fumarate transfer into human milk
por: Ciplea, Andrea I., et al.
Publicado: (2020)

Drug-Repurposing Strategy for Dimethyl Fumarate
por: Giunta, Salvatore, et al.
Publicado: (2023)

Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination
por: Espitia Pinzon, Nathaly, et al.
Publicado: (2017)

Ultrastructural Evidence of Synapse Preservation and Axonal Regeneration Following Spinal Root Repair with Fibrin Biopolymer and Therapy with Dimethyl Fumarate
por: Kempe, Paula Regina Gelinski, et al.
Publicado: (2023)

Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
por: Diebold, Martin, et al.
Publicado: (2022)

Dimethyl fumarate for treating Papillon–Lefèvre syndrome
por: Al-Omair, Abdullah, et al.
Publicado: (2022)

The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies
por: Manai, Federico, et al.
Publicado: (2022)

Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling
por: Jin, Lingting, et al.
Publicado: (2022)

Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera(®) (Dimethyl Fumarate)
por: Lategan, Thomas W., et al.
Publicado: (2021)

Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis
por: Licht‐Mayer, Simon, et al.
Publicado: (2022)

Beneficial actions of the anti-inflammatory dimethyl fumarate in glioblastomas
por: Ghods, Ali J., et al.
Publicado: (2013)

Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes
por: Huang, He, et al.
Publicado: (2015)

Prevention of Autoimmune Diabetes in NOD Mice by Dimethyl Fumarate
por: Li, Shiri, et al.
Publicado: (2021)

Effectiveness and safety of dimethyl fumarate in progressive multiple sclerosis
por: Moreira Ferreira, Vanessa F, et al.
Publicado: (2021)

Comparison of dimethyl fumarate and interferon outcomes in an MS cohort
por: Sattarnezhad, Neda, et al.
Publicado: (2022)

Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination
por: Campbell, Graham R., et al.
Publicado: (2011)

Optical measurement of conduction in single demyelinated axons
Publicado: (1990)

Axons and Neurons in Corona Virus-Induced Demyelination
por: Dandekar, Ajai A., et al.
Publicado: (2005)

Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective
por: Nicaise, Charles, et al.
Publicado: (2019)

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase
por: Hoffmann, Christina, et al.
Publicado: (2017)

Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance
por: Longbrake, Erin E, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rosg4hgfg6010bv80hij682h1f