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Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad of cellular events, such as gene transcription, mitochondria biogenesis, insulin secretion as well as glucose and lipid metabolism. From a mechanistic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922766/ https://www.ncbi.nlm.nih.gov/pubmed/33670751 http://dx.doi.org/10.3390/biom11020312 |