Development and Validation of an LC-MS/MS Method for Quantification of the Novel Antibacterial Candidate DA-7010 in Plasma and Application to a Preclinical Pharmacokinetic Study

DA-7010 is a new candidate for an antibacterial agent that targets Gram-negative pathogens by acting as a leucyl-tRNA synthetase inhibitor. In this study, a simple and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to determine DA-7010 levels in the plasma from...

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Detalles Bibliográficos
Autores principales: Kwon, Mi Hye, Lee, Dae Young, Kang, Hee Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922803/
https://www.ncbi.nlm.nih.gov/pubmed/33670597
http://dx.doi.org/10.3390/ph14020163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922803/
https://www.ncbi.nlm.nih.gov/pubmed/33670597
http://dx.doi.org/10.3390/ph14020163

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