The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades

Little is known about the effects on hyaluronan (HA) metabolism of UVA radiation. This study demonstrates that the secretion of HA by human dermal fibroblasts (HDFs) is downregulated by UVA, accompanied by the down- and upregulation of mRNA and protein levels of the HA-synthesizing enzyme (HAS2) and...

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Detalles Bibliográficos
Autores principales: Terazawa, Shuko, Takada, Mariko, Sato, Yoriko, Nakajima, Hiroaki, Imokawa, Genji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922819/
https://www.ncbi.nlm.nih.gov/pubmed/33669634
http://dx.doi.org/10.3390/ijms22042057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922819/
https://www.ncbi.nlm.nih.gov/pubmed/33669634
http://dx.doi.org/10.3390/ijms22042057

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