Molecular Dissection of Escherichia coli CpdB: Roles of the N Domain in Catalysis and Phosphate Inhibition, and of the C Domain in Substrate Specificity and Adenosine Inhibition

CpdB is a 3′-nucleotidase/2′3′-cyclic nucleotide phosphodiesterase, active also with reasonable efficiency on cyclic dinucleotides like c-di-AMP (3′,5′-cyclic diadenosine monophosphate) and c-di-GMP (3′,5′-cyclic diadenosine monophosphate). These are regulators of bacterial physiology, but are also...

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Detalles Bibliográficos
Autores principales: López-Villamizar, Iralis, Cabezas, Alicia, Pinto, Rosa María, Canales, José, Ribeiro, João Meireles, Rodrigues, Joaquim Rui, Costas, María Jesús, Cameselle, José Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922932/
https://www.ncbi.nlm.nih.gov/pubmed/33671286
http://dx.doi.org/10.3390/ijms22041977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922932/
https://www.ncbi.nlm.nih.gov/pubmed/33671286
http://dx.doi.org/10.3390/ijms22041977

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