Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading t...

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Detalles Bibliográficos
Autores principales: Flude, Ben M., Nannetti, Giulio, Mitchell, Paige, Compton, Nina, Richards, Chloe, Heurich, Meike, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923061/
https://www.ncbi.nlm.nih.gov/pubmed/33671334
http://dx.doi.org/10.3390/v13020312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923061/
https://www.ncbi.nlm.nih.gov/pubmed/33671334
http://dx.doi.org/10.3390/v13020312

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