Binding of Amyloid β(1–42)-Calmodulin Complexes to Plasma Membrane Lipid Rafts in Cerebellar Granule Neurons Alters Resting Cytosolic Calcium Homeostasis

Lipid rafts are a primary target in studies of amyloid β (Aβ) cytotoxicity in neurons. Exogenous Aβ peptides bind to lipid rafts, which in turn play a key role in Aβ uptake, leading to the formation of neurotoxic intracellular Aβ aggregates. On the other hand, dysregulation of intracellular calcium...

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Detalles Bibliográficos
Autores principales: Poejo, Joana, Salazar, Jairo, Mata, Ana M., Gutierrez-Merino, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923178/
https://www.ncbi.nlm.nih.gov/pubmed/33671444
http://dx.doi.org/10.3390/ijms22041984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923178/
https://www.ncbi.nlm.nih.gov/pubmed/33671444
http://dx.doi.org/10.3390/ijms22041984

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