Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth

RIDR-PI-103 is a novel reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103). Under high ROS, PI-103 is released in a controlled manner to inhibit PI3K. The efficacy and bioavailability of RIDR-PI-103 in breast cancer remains...

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Detalles Bibliográficos
Autores principales: Mishra, Rosalin, Yuan, Long, Patel, Hima, Karve, Aniruddha S., Zhu, Haizhou, White, Aaron, Alanazi, Samar, Desai, Pankaj, Merino, Edward J., Garrett, Joan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923228/
https://www.ncbi.nlm.nih.gov/pubmed/33669867
http://dx.doi.org/10.3390/ijms22042088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923228/
https://www.ncbi.nlm.nih.gov/pubmed/33669867
http://dx.doi.org/10.3390/ijms22042088

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