The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker?

In this study, we assessed the potential use of the 1β-hydroxy-deoxycholic acid (1β-OH-DCA) to deoxycholic acid (DCA) urinary metabolic ratio (UMR) as a CYP3A metric in ten male healthy volunteers. Midazolam (MDZ) 1 mg was administered orally at three sessions: alone (control session), after pre-tre...

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Detalles Bibliográficos
Autores principales: Magliocco, Gaëlle, Desmeules, Jules, Bosilkovska, Marija, Thomas, Aurélien, Daali, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923269/
https://www.ncbi.nlm.nih.gov/pubmed/33672438
http://dx.doi.org/10.3390/jpm11020150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923269/
https://www.ncbi.nlm.nih.gov/pubmed/33672438
http://dx.doi.org/10.3390/jpm11020150

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