On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet

The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II drug, from the orally administered commercial immediate-release tablet (Xarelto IR) using physiologically based pharmacokinetic (PBPK) and conventional in vitro–in vivo correlation (IVIVC) models. The bioava...

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Detalles Bibliográficos
Autores principales: Kushwah, Varun, Arora, Sumit, Tamás Katona, Miklós, Modhave, Dattatray, Fröhlich, Eleonore, Paudel, Amrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923293/
https://www.ncbi.nlm.nih.gov/pubmed/33672439
http://dx.doi.org/10.3390/pharmaceutics13020283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923293/
https://www.ncbi.nlm.nih.gov/pubmed/33672439
http://dx.doi.org/10.3390/pharmaceutics13020283

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