A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications

BACKGROUND: Non-targeted cytotoxics with anticancer activity are often developed through preclinical stages using response criteria observed in cell lines and xenografts. A panel of the NCI-60 cell lines is frequently the first line to define tumor types that are optimally responsive. Open data on t...

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Detalles Bibliográficos
Autores principales: Kathad, Umesh, Kulkarni, Aditya, McDermott, Joseph Ryan, Wegner, Jordan, Carr, Peter, Biyani, Neha, Modali, Rama, Richard, Jean-Philippe, Sharma, Panna, Bhatia, Kishor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923321/
https://www.ncbi.nlm.nih.gov/pubmed/33653269
http://dx.doi.org/10.1186/s12859-021-04040-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923321/
https://www.ncbi.nlm.nih.gov/pubmed/33653269
http://dx.doi.org/10.1186/s12859-021-04040-8

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