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A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications
BACKGROUND: Non-targeted cytotoxics with anticancer activity are often developed through preclinical stages using response criteria observed in cell lines and xenografts. A panel of the NCI-60 cell lines is frequently the first line to define tumor types that are optimally responsive. Open data on t...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923321/ https://www.ncbi.nlm.nih.gov/pubmed/33653269 http://dx.doi.org/10.1186/s12859-021-04040-8 |